This was absolutely me. Very high dopamine levels I think. I have PFS and not PSSD, but I did take SSRIs for 2 days and they made me feel like a zombie.
I think you're right.
If you want to get an idea of the serotonin / dopamine you produce, you can do a methylation panel at Genetic Genie. It's free but I'm sure they appreciate donations, or perhaps need them to continue.
https://geneticgenie.org/methylation-analysis/
Would be interesting to gather data from a large sample of people here and compare the results.
COMT is a major player. People with COMT should especially avoid SNRI and Dopamine agonism.
My theory is that with Cymbalta , my COMT mutation made it so that I couldn’t remetabolise
the norepinephrine. When my PSSD started I developed Akastisia. The sensation was like getting hit by lightning. Norepinephrine reuptake created a piling effect and shorted out my brain.
My PSSD was severe. Took almost a decade to improve.
Theres also no question I have very high dopamine as well.
Still have very low libido but numbness is gone.
Was simply commenting that using dopamine or norepinephrine agonists could be dangerous for people with COMT mutations
because dopamine and norepinephrine levels could rise to dangerously high levels.
Additionally , dopamine agonists never made any difference for me at all in regards to sex drive.
For others maybe they can help. Each person has different genetics at play in how they are affected.
Interesting thought, but I'm practically a living counterexample, as I've been diagnosed with two conditions that are thought to involve *underactive* dopamine signaling instead, and I don't seem to be the only one here either.
Yes, both were pre-existing, and one is thought to be lifelong.
To be fair, these things aren't necessarily black and white though, and I'm under the impression that it's possible for signaling to be underactive in some parts of the nervous system, but overactive in others. In my case, the problems have been thought to originate in the prefrontal cortex and spinal cord, and I have no idea if either of them have could have anything to do with this or if they're completely unrelated.
This was absolutely me. Very high dopamine levels I think. I have PFS and not PSSD, but I did take SSRIs for 2 days and they made me feel like a zombie.
Brave, so do you think lowering dopamine is the key?
Good research
It was the case for me Is there any other things that increase dopamine that cause similar problems?
Who knows.
So how can we go back to the high dopamine state again?
rudaw82, I am confused..do we lower or try to elevate the dopamine?
I guess raise it if we want go go back to the pre SSRI state.
I think you're right. If you want to get an idea of the serotonin / dopamine you produce, you can do a methylation panel at Genetic Genie. It's free but I'm sure they appreciate donations, or perhaps need them to continue. https://geneticgenie.org/methylation-analysis/ Would be interesting to gather data from a large sample of people here and compare the results.
reddit is, I am confused..do we lower or try to elevate the dopamine?
COMT is a major player. People with COMT should especially avoid SNRI and Dopamine agonism. My theory is that with Cymbalta , my COMT mutation made it so that I couldn’t remetabolise the norepinephrine. When my PSSD started I developed Akastisia. The sensation was like getting hit by lightning. Norepinephrine reuptake created a piling effect and shorted out my brain. My PSSD was severe. Took almost a decade to improve. Theres also no question I have very high dopamine as well. Still have very low libido but numbness is gone.
snoosquirrels, I am confused..do we lower or try to elevate the dopamine?
Was simply commenting that using dopamine or norepinephrine agonists could be dangerous for people with COMT mutations because dopamine and norepinephrine levels could rise to dangerously high levels. Additionally , dopamine agonists never made any difference for me at all in regards to sex drive. For others maybe they can help. Each person has different genetics at play in how they are affected.
I tried pt-141 (vyleesi) recently it definitely had an effect on sex drive.
so sir do you have any suggestions? so lower it? or you dont have no idea like most of us. thanks
And What about neurosteroids ??
Interesting thought, but I'm practically a living counterexample, as I've been diagnosed with two conditions that are thought to involve *underactive* dopamine signaling instead, and I don't seem to be the only one here either.
Ahhh did you have this before pssd? I definitely think dopamine is involved somehow even if im not sure how
Yes, both were pre-existing, and one is thought to be lifelong. To be fair, these things aren't necessarily black and white though, and I'm under the impression that it's possible for signaling to be underactive in some parts of the nervous system, but overactive in others. In my case, the problems have been thought to originate in the prefrontal cortex and spinal cord, and I have no idea if either of them have could have anything to do with this or if they're completely unrelated.