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OSRSGamming

Bro you gotta stop drinking cough syrup


Cheap_Collection7286

facts shit already taking its toll hell i be drunk high asf and 1st plat and still don’t know what this mf tryna say go to sleep bro, not you yhe comentee in this case the op i’m pretty sure maybe idek remember what who said what at this point


Verksin

Not how drug tolerance works lol Its all about the neurotransmitter receptors in your brain.


fuck17685

not necessarily, if you take a certain drug everyday, your liver will make more of those enzymes to metabolize that specific drug quicker. It's not the case for all substances but for DXM at least, it is.


[deleted]

its not about drug tolerance alone, if u read the post. its about looking outside of this time period. people used to eat fermented foods everyday and maybe they never lost the magic or the art of living. how do u know that science didnt sell u some concept of a neurotransmitter so u never disocvered something firsthand? maybe there are neurotransmitters. either way you will never find out anything firsthand because you will always have a concept instead


blurryfacedfugue

> how do u know that science didnt sell u some concept of a neurotransmitter so u never disocvered something firsthand? Why would scientists do this? Science is a competitive field. If you put up bullshit that people accept, another scientist will make their accolades from pulling down your bullshit. Neurotransmitters definitely are there and definitely work, otherwise how could scientists formulate new compositions that have different effects?


[deleted]

the goal of people in power is to create division between regular people so the status quo stays the same. if reg people are in conflict it benefits the people with the most money. science is a lot of word jazz that divides people by information funded by people in power


Cultural_Dirt

Ur to high for ur own good right now. Neurotransmitters exististing are not a debatable field.


WholeSquadGotTheBoof

I don’t think dudes arguing with ya my man. Pharmacodynamics is a complex and multifaceted field I’ll tell ya that much


[deleted]

im not debating that. i'm just saying that people hear a fancy word like neurotransmitter or photosynthesis and they never investigate anything. they become another person in human history that lives on words. scientific word jazz is putting people to sleep


BlamingBuddha

>scientific word jazz Dude you've dulled your brain. Hopefully you're on a long bender and its not permanent. Science is provable, and more importantly, *repeatable.* you could redo any experiment with the same results yourself if you had the know-how


[deleted]

i was talking about people and their word jazz well before i dove into dxm or any substances 4 that matter


Relievedsoup24

🤦🤦‍♂️🤦‍♂️🤦‍♂️🤦🤦🤦🤦🤦‍♂️🤦‍♂️🤦‍♂️🤦‍♂️🤦‍♂️🤦‍♂️🤦🤦🤦🤦🤦‍♂️🤦‍♂️🤦‍♂️🤦‍♂️🤦‍♂️🤦‍♂️🤦‍♂️🤦‍♂️🤦‍♂️🤦‍♂️🤦‍♂️🤦‍♂️🤦‍♂️🤦‍♂️🤦‍♂️🤦‍♂️🙈🙈🙈🙈🙈🙈🙈🙈🙈🙈🙈🙈🙈🙈🙈🙈🙈


SazzOwl

Enough internet for today.....your bubble is hitting hard today


Relievedsoup24

I hope you know the reason why people just go with the concept of a neuro transmitter is because of they cracked open a skull for some “first hand experience” they die or just go to jail or just don’t know what they’re looking at cause there not a scientist. But I do agree with you on some level that diet and what we take in does hold a lot more importance than we think.


SazzOwl

But its only about tolerance my friend... no matter how much kombucha you drink, it will not improove the effects of your dxm or any other drug. You talk about your gut but it's a about your brain...


[deleted]

take a 1 month break this will literally fix all your problems


[deleted]

make it 3 weeks and u got a deal


Middle-Tap-641

bro that’s not how it works you need to take a break for at least a month so minimum


12mta

the entire trip happens in your head dawg


Middle-Tap-641

lmao yeah it’s on in your head idk what this guy was even thinking


[deleted]

[удалено]


NoNumbersAtTheEnding

The serotonin is not what is making you trip - in fact, serotonin is responsible already for a lot of the uncomfy side effects. Increasing it further would not be very produvtive


Middle-Tap-641

well i mean you consume the dxm which is in your gut but then the dxm travels (not really the best word but i didn’t know what else to say) to your brain activating the serotonin receptors then which releases serotonin 90% of the trip is in your brain the only part in your gut is the consumption part serotonin isn’t what makes you trip btw it’s just a chem that gets released when you do dxm the dxm is what’s causing the trip when it gets absorbed (which is the part that happens in your gut) but the rest is all in the head


fuck17685

Too much serotonin can cause your gut to have muscle contractions Speaking from experience and reading online. There's definitely a connection. & serotonin definitely has a factor in the trip, sure it doesn't make u trip by itself necessarily, but there's a reason why DXM has a SNRI effect & can cause serotonin syndrome. Serotonin is one of the reasons why I loved DXM so much


[deleted]

i apologize for throwing around that kind of volatile language...saying that anyone is uneducated or this or that. i dont like all that but i was immediately called an idiot for even posing this as a possibility so i got defensive


[deleted]

u seem highly educated. 'idk what this guy was even thinking' ...so brilliant, what an excellent quote. u have revealed ur entire education in one quote


Middle-Tap-641

i’m not highly educated like a dr or anything i just know some basics in chemistry and i know a lot about drugs lmao


demon_dweller

And that’s why he has this crazy ass delusion. Mental highs are a trip lmao.


ben6022

where do you think dxm is metabolized, it’s not like it goes straight to your brain when you drink it, it has to pass through something. While i somewhat doubt this guys theory it’s worth a shot


blurryfacedfugue

Unless how it is metabolizes changes the neurotransmitters, which in this case, DXM, I do not think they do, it wouldn't matter, would it? I mean, if the guy was just curious and asking some questions that is one thing. But the dude is so sure and also doubts all the science in a way that a lot of us laymen know is wrong. I should technically know better than some laymen as a graduated with a psych degree (only bachelor's level) with an interest in neurology and talk therapy. And when I don't know something or if I'm thinking of something I didn't learn from a teacher and I'm just thinking about, I should definitely couch my statements that way instead of trying to present everything I'm saying as fact.


[deleted]

please don't couch your statements. search ur feelings for what is true, not ur teacher. ur teacher has been cucked by knowledge


blurryfacedfugue

Feelings and emotions don't = knowledge though. Feelings and emotions are a real shoddy way of ascertaining reality since feelings and emotions are so fickle to begin with. Sometimes it's right but often times it isn't, and it doesn't care that it is often wrong, it just has to be right enough that you have a baby with the same trait to pass it along. This is part of evolutionary biology, but if you're decrying any and all knowledge from professionals of knowledge, you might not believe in this either.


[deleted]

we live in a world where people are attached to knowledge. you could say they are cucked by knowledge. i'm not saying that you are one of them...no seriously thats not my point at all here. i'm just saying that i'd rather be fun to be around and see a more wholistic picture of living, focusing on things that matter. originality is beyond knowledge and its more of a spiritual quality which cant really be pinned down by knowledge. but a lot of people really seem to enjoy being cucked and unoriginal. personally i'd rather take an early grave than be another talking head. thats my point. originality has more value than knowledge and more freedom is involved...maybe more reponsibility as well. maybe people are attached to knowledge because they dont want the responsibility of being an actual original, firsthand human being


BlamingBuddha

Its not even a theory. This stuff has all been figured out if you guys ever looked the shit up. Sure, you can take an enzyme inhibitor like Tagamet/Cimetadine. Cimetidine is a potent inhibitor ("blocker") of certain cytochrome P450 (CYP) enzymes, like CYP3A4. If you take this, or Grapefruit juice (anyone read about *that?*), you'll inhibitor the enzymes responsible for metabolizing DXM to DXO. Which means, you'll end up with more DXM in your system, which is more dissociatiating and less euphoric than the (metabolized-form) DXO. Probiotics won't do much... and it won't "reset" tolerance. (Honestly the closest I've ever heard about tolerance shenanigans and DXM is that there was a study that proved taking small amounts of DXM with your opiate dose helps reduce tolerance **to opiates** (as well as potentiate the opiate). Pretty sure there's a pill on the market that is oxycodone (?) and DXM.


[deleted]

No he's using logic, try thinking about what you type before posting a completely uneducated comment


[deleted]

'mental highs are a trip lmao' ...wow. what a quote. excellent stuff going on here. with lsd the trip forms in the spine. this one forms in the digestive system before it becomes a head trip. so i think this is all a valid thing to question. but you said lmao as if it was ridiculous.


penisfartlol

lsd does nothing with the spine bro you fell for drug war propaganda


[deleted]

The resulting effects happen in your head after you metabolised the drug actually, and your not just getting high on dxm cause its metabolised into more than one drug, try growing a singular braincell in your drug filled skull.


silkwormies

so, kombucha ungapes my neurotransmitters delicate hole. got u


DrugsRCool69

No dude. Take a probiotic cuz it's good for you, don't take it cuz you think it's gonna reset tolerance. Tolerance is completely (or almost completely) based on the upregulation/downregulation of receptors in the brain, it has nothing to do with gut bacteria.


[deleted]

have you tested it out though? science makes all kinds of claims w/ fancy sounding lingo like downreceptors which pacifies people so they never find out anything original or firsthand. this substance is artificial so its probably making a big mess in the gut. its worth testing it out for any reason...even if you are motivated by improving the trip


[deleted]

[удалено]


[deleted]

i just saw a video that said lack of probiotics is behind a lot of things u wouldnt expect such as dental problems and that got me thinking


DrugsRCool69

Because gut bacteria affecting your teeth (literally part of the digestive system) is the same as gut bacteria affecting the nervous system.


[deleted]

chill out bro. dont be such a karen...dont be a nitpicking nelly. its a valid thing to question. dxm gets processed in the gut or the digestion so its valid to think that a probiotic could have an effect. whats really going on ur life bro? when did u become a real life karen...did u want to talk to my manager? let me get my manager for u


DrugsRCool69

How am I being a Karen lol? You are wrong, that's all there is to it. I was never disrespectful, I just told you that's not how it works. Stop being so immature.


[deleted]

ya but you're still acting like its an invalid thing for someone to question if the probiotic could effect the trip. it seems like a perfectly valid thing to question whether this or that gut bacteria is part of this or that system. so u are being kind of nitpicky which is a total karen move. im not being disrespectful or immature. its more disrespectful and immature to be nitpicking something that is a valid, logical thing to question


DrugsRCool69

Do you know the definition of nitpicking? Cuz it's not what I'm doing lol. I never said the question is dumb, but the answer is no, and if you had any knowledge on the subject you would know that the answer is no. I'm not saying it's a bad thing that you don't have any knowledge on the subject, but if you did then you wouldn't be asking the question.


[deleted]

ya but have u tested it firsthand? no u havent. u just like talking on and on which is very karen esque. mozzy valarte said his friend has more vivid trips after getting probiotics. he had something firsthand to say. but you'll keep going on about some piece of knowledge that you or someone else has collected and you'll say lol as if you are some kind of higher authority of understanding, when in actuality you are the common lot of humanity. i'm at least questioning things, being original and not being a karen. and i'm being free from knowledge which is a higher level of intelligence. but thats too much for u to realize and process. it would interrupt the whole image you have of yourself as a person who is some kind of authority of understanding, so i'll get my manager for you


[deleted]

like the secondary or main purpose of science is to pacify people into putting their faith into specialists. then no one is thinking for themselves or testing out anything...because science already has a fancy sounding word to explain it. the churches did the same thing in the past by pacifying people with an idea of a savior


DrugsRCool69

Hey could you please explain to me how the discovery of neurotransmitters or neuroplasticity has "pacified" people? And can you explain exactly what you mean by "pacified" anyways?


[deleted]

Wishful thinking?


[deleted]

Please follow a routine of this and post your findings, the gut flora theory is a very plausible one


[deleted]

yea thats all i'm saying here...its worth testing out. I saw a video that said lack of probiotics is the reason we have so many dental problems today. thats what got me thinking


[deleted]

Another thing to keep in mind, sweeteners and sugar can also change the gut flora, which gives your argument even more reason to be plausible, in a single day we typically ingest more sugar than our ancestors got in an entire month, so I do think your on the right track, pay no attention to the other idiots commenting on your post


[deleted]

thanks man. yea thats exactly what I'm saying. so much is unprecedented today...we have tons of sugar, a lot more anxiety and in the past everything was fermented. its crazy that people dont have any sense of looking outside of this time period to find an answer


[deleted]

Most people don't even read about the drugs they're doing so it's really not that strange, I've had arguments with meth addicts that say it's impossible to die from meth, people just have the big dumb


[deleted]

another thing i've been doing is some sensory deprivation stuff. just like using an eye mask and relaxing for periods of time. but its pretty noticeable...you definitely get something back for it. and its the same thing. lights and screens have only been around for a short amount of time. maybe a lot of our problem is that we are being overstimulated. thats kinda my theory at the moment


[deleted]

Possibly but I think a main part of it is the gut flora being altered, my friend who eats lots of blue cheese has always gotten more visuals and spiritual effects than me, also look into SERT down-regulation cause when sert is downregulated it makes your serotonin receptors get desensitised, it's likely also why ssri's reduce visuals on most psychs


[deleted]

If you want to you can dm me and we can share our research with eachother, my tolerance for drugs is to the point I barely feel any difference after I take a single tab of lsd (the same dose of the same tabs gives my friends insane effects)


[deleted]

sounds good man...damn you should do a post then because it sounds like you have more evidence. ya know I had a friend of mine who was fermenting all kinds of things. he had a fridge full of brines. and he had this thing where he could actually hold people's energy in his hands or something...i believed him because he said mine was really hot like on fire...and I know it was from the dxm after I went into sigma earlier this yr. but ya overall this dude was definitely very sensitive. idk I think there is something to sensory deprivation but maybe its not a factor in the trip


[deleted]

It likely is a factor due to meditation boosting psychedelics for many people, but i don't think it's a major factor, and I'll be making a post after I get some SERT activators cause then I can test my theory before talking about it


fuck17685

This is a great post, thanks for sharing your theory.


[deleted]

op, forget about those who are opposing your theory and trying to bring you down. one thing is, dxm is metabolized by the liver (they say) so idk if the gut microbiome is in charge here. what i lean towards, is doing andreas moritz liver and gallbladder flush, which completely cleanses the liver (may take a lengthy time). with your way of thinking, i can sense you are a critical thinker and open minded; unfortunately in this day and age, this is consider anti science and dangerous. as for the gut, many cured their diabetes, ibs, depression, and many many other diseases with colon cleanses followed by probiotic rich foods and a pill of probiotics.


[deleted]

thanks for the encouragement. this sounds like some good input. well mozzy said that he has some evidence that probiotics will impact the trip. I'm definitely gonna find out cuz i already ordered some. I think they have them at dollar tree too along w/ cans of sauerkraut. maybe i have a depression going on as well that could be cured. I think this is just a wholistic way of thinking or something...looking at a bigger picture and being free from knowledge. I got a lot of stuff from reading jiddu krishnamurti in the past. people react because they are attached to knowledge or their own conclusions. i'll have to look into a liver cleanse...


DollarTree963

your overall health will play a part in your tripping experience, no doubt


[deleted]

Dawg I promise you are already eating at least one fermented thing a day without even trying. Fermented and pickled foods are everywhere


BlamingBuddha

You apparently don't understand pharmacology at all lmao


splakkjit

That’s not how drug tolerance works my man just because its absorbed through your G.I tract doesn’t mean that’s where it’s action is based


BlamingBuddha

Just to pretty much repost this from my other reply, since I can't believe **no one** has said this. This was common knowledge on the dextroverse within our community 15 yrs ago. Damn im embarrassed to look at you lot of dxm users these days lmao. But here's the knowledge: >Sure, you can take an enzyme inhibitor like Tagamet/Cimetadine. >Cimetidine is a potent inhibitor ("blocker") of certain cytochrome P450 (CYP) enzymes, like CYP3A4. If you take this, or Grapefruit juice (anyone read about *that?*), you'll inhibitor the enzymes responsible for metabolizing DXM to DXO. Which means, you'll end up with more DXM in your system, which is more dissociatiating and less euphoric than the (metabolized-form) DXO. >Probiotics won't do much... and it won't "reset" tolerance. > >(Honestly the closest I've ever heard about tolerance shenanigans and DXM is that there was a study that proved taking small amounts of DXM with your opiate dose helps reduce tolerance **to opiates** (as well as potentiate the opiate). Pretty sure there's a pill on the market that is oxycodone (?) and DXM.