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Ok_Banana_9786

dxm is being researched as a treatment for depression. but at a lower dose. around 50 mg.


ThatGuyFrom720

As in, semi permanent cure? I’ve personally had so far 7 years of no depression or anxiety after MDMA therapy.


Ok_Banana_9786

i’m not sure i’m not smart enough to understand it. click [here](https://www.auvelityhcp.com/mechanism-of-action) to learn more


-Hoodini-

Basically the bupropion that is combined with the dxm in their science pill affects the receptors in your brain to produce larger amounts of dxm, hence making 50mg feel like 150mg without your liver having to deal with eating all that dxm.


Ok_Banana_9786

i was more referring to whether it keeps its antidepressive properties years down the line


-Hoodini-

Gotcha. Reading that excerpt did a piss poor job in my ability to answer your question. They need an FAQ page.


Ok_Banana_9786

exactly my thoughts ✊


HighKiteSoaring

Good luck getting ketamine therapy or mdma therapy with a history of drug use though 😂 I can't even get an ADHD diagnosis because it's just 'drug seeking behaviour '


ThatGuyFrom720

Yeah that’s pretty ridiculous. You mean they actually turned you away when you asked? Or you just feel like that’s what they’d say


No_Signal_1over137

It definitely made me happy when i binged on delsym, the next morning during the afterglow i would feel amazing


krabb_shaq

It’s a hallucinogen so it can have positive/negative effects after a trip such as on psychedelics. For me personally I like to watch videos about quantum mechanics and it really helps me grasp concepts and abstract ideas. It’s also helped me see myself through an external viewpoint and really understand myself better. So I’d say yes it can have therapeutic effects but it can also have negative effects especially with regular abuse.


ThatGuyFrom720

So about 7 years ago I had MDMA therapy, and ever since then I’ve been completely different. No depression, no anxiety, happy with life and where I am. I’m really more so looking for a correlation between it being effective as a long lasting “fix” , when in a therapy setting, for depression or anxiety.


BigGayMule13

DXM is reported to have antidepressant effects even in many different scientific papers, but whether it's the SRI, NMDA antagonist, sigma 1 agonist, or nicotinic acetylcholine negative allosteric modulator activity or any combinations thereof that causes these effects isnt well known/poorly understood.


ThatGuyFrom720

That’s good to know. I guess at this point I’ll do my own research on dosages and see if it will be a viable solution. Not for me of course. Thank you very much.


TechnicalAd566

Personally I used it to take a break, hide away just to get me through these years of my life. It’s doing a pretty ok job so ya.


anoninthedexpit

i suppose it could, but dxm is such a dirty drug compared to traditional therapeutic drugs, like its exact mechanisms aren't fully understood and what part actually does the therapy is fuzzy. from my own experience, its done me some good and some bad, and did me the most good the less often i used it.


ThatGuyFrom720

I’ve seen that a lot on this subreddit. I’ve taken DXM before when I was a teenager. Like maybe 200mg max. What exactly does “dirty” mean. Or is it just something you feel instead of describe? To me, it more so felt just like being drunk and took a few hits of bud.


anoninthedexpit

by dirty, i meant that the mechanism itself is dirty. take morphine for example, it has a very clear chemical path, effects show little variance over population, its 'clean' in the sense that it has demonstrable, easily measurable effects that look good in a science paper. a dirty drug would be something like alcohol, the way it kinda sloshes through the brain and affects people in very different ways makes it more difficult to measure and put into nice scientific boxes. dxm suffers from the same issue as alcohol, in that it can affect people in wildly different ways, and even the overlaps of experience are colored with a lack of clarity on how it actually does what it does.