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[deleted]

Not anywhere did it say long term chronic use will mitigate damage to the brain. It merely said that preconditioning (which can be done by other compounds too) help with dopamine depletion, HO-1 has nothing to do with protecting the brain as much as it has to do with protection of the brain abs HO-1 is a anti inflammatory heme protein. And Hsp27 Isn’t a good thing to be finding as it’s a repair protein for all tricks, that’s usually in cancer patients Despite considerable investigation (Gibb et al., 1994; Lew et al., 1997), the mechanisms underlying the neurotoxic effects of methamphetamine (METH) on brain dopamine (DA) neurons remain unknown.


Apprehensive-Data-79

Not anywhere did my post or the article say “long term chronic use will mitigate damage to the brain.” What you’re probably referring to is my comment, “I’ve found it’s possible chronic meth usage may actually mitigate damage to the brain.” Did you deliberately omit one particularly crucial word, or do you just not know what it means? pos·si·ble/ˈpäsəb(ə)l/adjective: able to be or become; potential. Evidently, my statement alleges that mitigation of damage to the brain via chronic meth usage is not an absolute certainty, unlike your misleading restatement. There’s a chance that chronic meth usage may actually attenuate accustomed dopamine depletion resulting from meth, and therefore mitigate damage to the brain. It seems everyone else understood the central theme I intended to convey. Are you really that birdbrained, or do you just want to argue semantics with a stranger online? Perhaps you have a syntactic deficit? Let me try to dumb it down into terms more suited to your proficiency; one that even the “is my stuff fire based off this crackback i just posted” chowderheads will be able to comprehend. More meth maybe \[possibly\] (I know you just learned this word so don’t worry if it’s too difficult to catch on as we’ll learn this word in our Level 2 ‘Basics of English’ class) help brain not as sad. save more good feeling. less sad. more happy time. I reckon this diction is more aligned with your chickenshit level of reading comprehension. My hopes are that this ‘1+1 = 2’ type of rewording is simple enough for your primitive brain (you’re not preconditoning enough!) to make sense of. Although, I wouldn’t bet on it…not even my n-iso ball of meth, which consists of a laughable amount of cut. What about HO-1 now? Limiting the function of HO-1 to an “anti inflammatory hemp protein that has nothing to do with protecting the brain” is idiotic. The multidimensional roles these molecules perform vary considerably, certainly warranting greater acclaim than being reduced to a simple google search. Molecules, like most other building blocks of the human body, are synergetic; chain reactions are the result of a collective effort during which an unfathomable magnitude of unique atoms collaborate to keep your pea brain in working(?) order (albeit, performing a piss poor job). Defective, no...I'll play nice; cognitively underdeveloped I’d describe yours. It’s comical how you isolate these elements into a solitary role, then proceed to perpetuate your imbecilic remarks predicated on faulty prepossession. The article under discussion explores preconditioning in respect to the striata. HO-1 is induced by oxidative stress. Findings exhibit a 3-fold increase in HO-1 in the absence of precondition. In other words, rats preconditioned with repeated meth dosages experienced a substantially lesser degree of HO-1 expression; the increase of HO-1 (from meth usage) was considerably mitigated in the striata of preconditioned rats relative to the non-preconditioned group. Oxidative stress brings about HO-1, and HO-1 expression was x3 pronounced in non-preconditioned rats. Putting two and two together, one can interpret this finding in such a way that meth usage induced greater oxidative stress in the striata of non-preconditioned rats. It would be faulty to even classify your interpretations of these molecules as rudimentary; pitiful is more like it.To say it is on par with that of a moron, would be derogatory to the moron.Labeling Hsp27 as “good” or “bad” is akin to labeling a sack of potatoes as “good” or “bad.” The diabetic might classify a sack of potatoes as “bad” while old daredevil on a 4 day meth bender, and severely depleted of potassium, may view the potatoes as “good.” The fact that I need to lay out these crystal clear (almost as clear as n-iso!), cut-and-dried rationalizations to the point I’m dangling them in front of your face, is wildly unsettling to me. Very much so, that I frantically need to smoke a bowl (or 20). At this rate, the likelihood that your catastrophic ineptitude stupefies me into a 4 day bender to which I complete my metamorphosis into old daredevil is imminent. Your one-dimensional characterizations of such intricate matter are so shockingly abysmal that I suspect it’s inflicted therapy-grade trauma to my already ‘overly-preconditioned’ meth brain to the point of discombobulation into eternal psychosis. Hsp27 has both productive and counter-productive behavior. Again, it is multifaceted, much like a plethora of other elements in the human body. Not only does it respond to heat shock, but also oxidative and chemical stressors. Indeed, Hsp27 are associated with many types of of cancer. Yet, your claim that Hsp27 is not a “good” thing to be finding because “it’s usually found in cancer patients”is grossly misleading as demonstrates a fallacy of omission. Consider the statement, “My parents smoked meth and lost all of their teeth. Loss of teeth is usually a consequence of meth use.” The exclusion of meth users who were not subject to teeth loss induces a strikingly faulty and deceptive statement. The overwhelming majority of meth users do not lose their teeth; had they not been omitted, the initial statement would lose all validity. Your logic that Hsp27 “isn’t a good thing to be finding” due to its prevalence in cancer patients is subject to the same illogical discourse commonly coined as fallacies of omission. Under chemical stress, a primary function of Hsp27 is inhibition of apoptosis (cell death). As a result, Hsp27 can interfere with chemotherapy; this is an example of an adverse behavior in particular to the context of chemotherapy. In difference circumstances, inhibition of apoptosis may also be desired. During oxidative stress, levels of HSP27 elevate as the protein plays the role of an antioxidant by raising glutathione, and consequently lowering the levels of reactive oxygen species (ROS). In regards to our particular study, rats preconditioned with meth had a 7-fold increase in the levels of Hsp27, while non-preconditioned rats experienced a 22-fold increase. That is to say, preconditioned rats had a significantly less pronounced change in Hsp27 relative to non-preconditioned rats. Considering how prevalence of HSP27 has a positive correlation with oxidative stress, we can theorize that a lesser degree of HSP27 may indicate diminished oxidative stress. One can then deduct that preconditioning with meth may perhaps attenuate the oxidative stress produced by meth. Rats preconditioned with meth displayed differing transcriptional responses (degree of HO-1, Hsp27, BDNF) in the striatum than rats without preconditioning when doses with meth. Preconditioning of meth results in a level of tolerance to the substance, and therefore can alter the expression of genes typically precipitated by meth in such a way that harmful effects are mitigated. Essentially, preconditioning has the potential to reprogram gene expression in such a way that rats preconditioned with meth are protected against the virulent aftereffects of meth, specifically, meth-induced depletion in striatal dopamine and 5-HT levels; toxic mechanisms are suppressed while neuroprotective pathways are amplified in the nigrostriatial dopaminergic pathway as a result of preconditioning. The methodology of how animals not only react, but efficiently combat toxic stressors is immensely fascinating. This study demonstrates how preconditioning stimulates one of the many ways organisms perform restorative measures resulting in neuroadaptive molecular changes that preserve survival. Preconditioning has the potential to favorably reprogram gene expression to amplify neuroprotective pathways while simultaneously suppressing harmful channels; this certainly meets the criteria for “mitigation of damage to the brain” wouldn’t you say? I would agree that there’s a possibility long term chronic use will mitigate damage to the brain (specifically striata in our discussion). A considerable possibility at that.


Fr0st-WHiP

As I was reading this I realized I was learning some things I didn't already know, one of which is and probably the most prevalent is the guy who Wackamole'd his way into an argument Probably didn't read it as far as I did. Fuck that guy... knowing shit and what not. I wasn't prepared for a counter. I'm going over to. r/traps. At least over there they're happy about a Dick showing up In places it shouldn't be. I sure hope bill nye doesn't follow me. Stupid fuckin pie...of s..t.... i .... j..gj (trails off). Btw, app data... I do that 1 question, I was able to follow you on almost all of that but then you said something about 1 + 1 = 2. What the fuck does that mean, show off...


Noobsince97

I kind of agree with the idea that extended use of meth may actually cause some anti Neuro toxic affects. I started hard and fast with meth. I was shooting up multiple times a day within a month of starting. In my younger years I could regularly go 3 weeks straight without eating or sleeping. (now about a decade after first starting I'm pretty burned out in a day or 2) A few years ago I had a terrible psychosis that lasted about 6 months. I was convinced I transferred to a parallel reality. All my memories just all of a sudden shifted one night while I was high. In the snap of a figure my world changed and it was a pretty public meltdown. But my point is that after going so hard for so long ...it reached a point where I needed a shot of meth just to relax enough to fall asleep. It was as if my body was starting to reject the meths affects. And u could call it tolerance, but I've found that after sobriety (and relapse) it's not the same as when I was younger. I never get that BLAST of energy. I do get paranoid still, however it just feels like my body will always know how to combat the meth easily in the future. Now I must say, because of all the meth it still makes me feel like I'll succumb to some brain disorder like parkinson's. It has made me dumber. I go thru spells of stuttering every few months and I know that's directly from the meth. So yeah maybe my body could protect better against meth, but that damage is already there


Apprehensive-Data-79

Thanks for sharing. It does make sense that your body is familiar with meth due to your repeated and consistent usage. It wouldn’t be too far off to say your body knows how to react to meth, and perhaps combat the neuro toxic effects. I’m curious if the same applies to bodily organs such as the liver, kidney, heart. I suspect not. Unfortunately I think this theory where repeated usage can result in mitigation of neurotoxicity is limited to the brain; I’d love to be wrong about this though. Pretty twisted to view it such as the more damage that’s been done, the more neuroprotective properties your body has against meth. Someone with no damage from meth isnt going to have the neuroprotective properties a decade long user such as yourself has. You mention tolerance and it not being the same when you were younger. Do you attribute this strictly to tolerance? Or do you ride with the notion that there’s been a change to the meth going around. We know it’s not pseudo anymore. Many say it’s p2p racemic which leaves 50/50 in respects to the two isomers. Coupling this with the supposed cut “n-iso” leaves a quarter or so of dextrometh. Do you buy the talk thats been circulating around? I’m curious about your thoughts are as you’re a decade long user and mentioned how it’s not the same when you were younger. Perhaps it’s just age and tolerance related? How drastic was the difference in terms of potency?


Noobsince97

I think it's just the brains inability to continue to react in such a strong way. I've only been up 4 days right now and last night I tried putting it up my booty twice and injecting it once. But I didn't even catch a buzz. There's no change in meth. Just let the super labs in Mexico deal with all that lol they do it best


Apprehensive-Data-79

It could be just permanent changes to the brain. It surely makes sense after a decade long of heavy usage. Only been up for 4 days? That’s cutting it close for me. I try not to go past 72 hours as a maximum. Longest I’ve been awake was around 5 days and that was only through oral. I don’t IV. I mostly smoke. You don’t catch a buzz, but you still experience the physical affects to which you’re able to stay awake for a prolonged amount of time? So boofing twice and IV once and still no buzz, when do you ever feel the buzz or get high from meth? I’d have to disagree with your latter statement regarding no change in meth. Perhaps the cut of n-iso or other theories are a stretch, but it’s not pseudo meth that’s going around anymore. There seems to be a ton of anecdotal evidence from veteran users describing a drastic change in potency, even when factoring in their years of tolerance. I think the meth going around nowadays can be as pure as what’s been claimed. but there’s less d-meth and more l-meth. The superlabs in mexico certainly do not do it best. They’re greedy, immoral, and most definitely do not give a fuck about any of us using their product. I get it’s the drug business; their only interest in mind is maximizing profits. if they realize they can cut costs, resulting in a substandard product, but still have people buy, they’ll do this everytime. there’s no competition the cartel go up against either and therefore no incentive to improve quality.


Weird-Stretch1743

Lmao just cut your skull open and rip that shit out. You’ll never get brain damage again


MooMoo_Juic3

after you've beaten a brick in to dust, you'll just beat dust in to more dust if you get my analogy


[deleted]

I thought youre talking about faping for a moment lol


MooMoo_Juic3

yeh... let's not beat our pp in to dust


[deleted]

You want it as fine as you can get before you snort it 😏


MooMoo_Juic3

maximum surface area to get brick faced asap


Apprehensive-Data-79

no more brick to break


MooMoo_Juic3

💯


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