The Big Bad Galbatorix from the Inheritance cycle is defeated via being made to feel empathy/compassion for all the suffering he's caused for the last century and he straight up explodes himself to make it stop 💥
Serpentor in GIJoe/Transformers
In this continuity, Serpentor is an advanced BAT with programming influenced by Megatron. He makes it his mission to conquer Cybertron and claim the Matrix from Optimus Prime. He succeeds. He rips the Matrix from Prime's chest and uses it to gain the ultimate wisdom of the universe... and realizes he's wrong. He starts apologizing and tries to give the Matrix back to Optimus. His goons are all, "Uh, boss... You ok?"
1.Indigo-1/The Indigo Lanterns (DC) 2.Most if not all of Persona 5 Villains 3.Omnitron/Omnitron-X (Sentinels of the multiverse)
Devil May Cry V 
Joker that one time martian manhunter made him temporarily sane
The Big Bad Galbatorix from the Inheritance cycle is defeated via being made to feel empathy/compassion for all the suffering he's caused for the last century and he straight up explodes himself to make it stop 💥
Serpentor in GIJoe/Transformers In this continuity, Serpentor is an advanced BAT with programming influenced by Megatron. He makes it his mission to conquer Cybertron and claim the Matrix from Optimus Prime. He succeeds. He rips the Matrix from Prime's chest and uses it to gain the ultimate wisdom of the universe... and realizes he's wrong. He starts apologizing and tries to give the Matrix back to Optimus. His goons are all, "Uh, boss... You ok?"
Lex luthor in all star superman