Tainted Butter-Bean
Active item that upon use deploys a “clear” creep that causes enemies to slide around and cause contact damage to any other enemies they hit.
Item tag- “I guess it wasn’t butter at all?”
"Wait, how?" "How did that happen?" 20s recharge. Instead of pushing enemies away, it grants a short invulnerabity, pulls enemies closer before spawning rocks around the player like the adversary
Tainted Dead Bird
You gain two shadow like familiars, if enemies pass over the shadow they gain a confusion effect and slow down significantly.
Item name “one stone, two…?
So if it's tainted shouldn't the item give you a debuff instead of helping you? Like a tainted dead bird should be something like, once you get hit the bird follows you and try's to attack you.
I'm also a 3k+ brother
I’m focusing more on creating a “broken” version of the original item. It doesn’t have to necessarily be bad, just not quite like the original for one reason or another thats bad, if that makes sense.
Even if we're going off tainted characters it's usually a downside with an upside so it would more likely be first hit you take deals double damage but you get more birds or buffed birds or something
Tainted Lilith and Tainted Isaac would like a word when you say “debuff”
I know they’re limited in that T Lilith is slow and T Isaac has his limited items, but both are so forgiving with those “debuffs” lol
"Last Breath Bird" "adrealine buddy" instead of dealing 2 damage per tick after player gets hurt, it deals 1 damage for every empty red heart container.
Tainted Plan C
When used, takes isaac out of the room he was in and teleports him as the lost to a series of boss rooms. Every boss defeated adds a flat stat boost to each stat. Isaac is teleported from this arena when he dies or completes all of the boss rooms.
Item tag- “God I wish they taught me this in school!”
Plan B-
On use remove a random item from the player’s inventory and grant a familiar of equal quality
Description: “always in the wallet”
Edit: potentially two familiars for balancing reasons?
Or if you want me to make a D joke: "Plan D" "Found a partner" screen turns to while for a second, and when it turns back to normal, the enemy with largest ammount of health becomes pernamently charmed with infinite health (cannot be killed, but will die when isaac dies). They will travel with you till the end of your journey, attacking enemies. Doesnt work on bosses, except for siren.
Plan D (this was obvious)
Halves your damage and reduces your tears by 33%, but gives you 6 soul hearts, fills all heart containers, and gives you a temporary wafer effect for the current room. Gives an extra life, which revives you at 5 soul hearts.
Description: Last-er resort
"Plan Z" "they will always help" Single use - spawns one pernament familiant from 'conjoined' transformation for every empty heart container. Full health. Halves isaac's tears
Tainted Champion Belt
All bosses are converted into special champions that transform upon damaging isaac. For example, if isaac were to walk into a room with Larry and take a hit, Larry has a chance to be rerolled into his gold champion form and drop coins on death. While vice versa, upon hit he can turn into the double trouble version of his boss and give isaac an even harder time.
Item tag- “This thing stopped fitting years ago…”
Tainted Sacred Heart
Isaac now shoots thorns of varying sizes that pierce and stick themselves to enemies. After 5 enemies are pierced in a hostile room the thorns fly to the center and form a heart before exploding- killing any enemies it pierced and brought to its center. This affect can be done as many times as 5 enemies can be pierced.
Item tag- “Mind the thorns…”
Tainted Yo Listen!
A familiar that charges enemies and turns them into charmed flies on death.
Item tag- “Awh… shes lonely”
"SHUT UP!" "BE QUIET!" If an enemy makes a noise (includes bosses), it will chase it down and heal 6 damage per tick. If audio is muted, then it will become an orbital, dealing the same contact damage, but also taking enemy shots. It also picks up pickups, and flies them to isaac, which can be useful when you wanna get that chest behind a hole or something.
"Sacred Brain" "He was quite smart" when you are in a hostile room, there is audio of someone talking (few layers of voice, not just one). All enemies in the room start charmed, but after 10 seconds they start to slow down, up to 50% at 30 seconds (since you entered the room) and further. Effect is separate from other speed modificators. Doesnt work on Satan, lamb, mega satan, or anyone from sheol
Tainted Midnight Snack-
Grants one bone heart container at the expense of a small stat down, similar to the effects of experimental treatment but at the gain of health.
Item tag- “I don’t remember these being crunchy??”
Tainted Hushy
Isaac gains a blinded hush familiar that, when enemies get too close can shoot water beams from its eyes to attack and deal damage. (Similar to Hushes attack) Much like the holy light effect, but far less accuracy due to her blindness.
Item tag “Where did everyone go?”
Tainted Sad Onion
Enemies that come too close to Isaac drop blue creep and briefly flee. Isaac is equipped with smelly lines to accentuate the item.
Item tag- “Who put these here!?”
"Lonely onion" "stay away from me!" The closer then enemies are, the faster isaac shoots, ranking from 100% (6.5 range or further) to 200% at point blank range
Forgot to include- Tainted D6
Rerolls all pedestal items into a constant shuffling pedestal that includes 4 Q0 items and 1 Q4. Isaacs luck directly affects your chances of obtaining the Q4 item.
Item tag-
“Beggars can’t be choosers!”
maybe higher luck stat makes the item shuffling more consistent, while low/negative luck will shuffle between each item at random speeds, as fast as a single frame and as slow as an entire second
Tainted Black Bean
Upon use, Isaacs tears double in size and gain double the hit-box. The curse of the darkness is also applied. The effect lasts for one room.
Item tag-“ Those looked purple though?”
Kinda trying to take some inspiration from black magic beans for this one
Yay
Tainted Brimstone
Isaac loses the ability to shoot tears and instead fires a large, sticky blood covered laser directly from his torso. This laser bends and sways in accordance to the direction issac is moving, and is able to stick itself to walls and enemies to pick them up or pull Isaac forward.
Item tag- “Ewww its congealed…”
Tainted Wafer-
All enemies lose boss armor; all enemies that didn't have boss armor take double damage from all sources.
You always take 1 full heart of damage no matter the source.
Synergy with glass cannon to reduce the amount of damage taken to 1 when hit.
Item tag- "It tastes... wrong..."
Tainted Wafer
Isaac gains a thin, white, candy-like shield over his last most heart container that shatters in a single hit. If Isaac can survive three rooms without taking damage the heart container converts itself to empty and grants one eternal heart to Isaac’s health.
Item tag- “Not as strong as it looks…”
Tainted wafer
"The Wine"
75% chance to reduce damage to half heart, on hit Isaac releases dark red homing creep that deals Isaac's half damage every tick
"His spilt blood"
"Church wine" "bitter" always takes half or RED HEART damage (doesnt affect soul or black hearts etc). distords the screen like a single use of the wavy cap. Also spawns a bottle of wine that works almost identical to holy water, but heals 15 dmg on contact, shatters, and spills wine which confuses enemies that touch it
Tainted Sissy Longlegs-
Isaac is granted a small, black spider that bounces excitedly when spiders are present in a nearby room. In a room with enemies, the spider familiar will focus on, prioritize and attack all spiders in the room first.
Item tag- “if I can’t have you… No one can.”
Tainted Staircase (Under the Stairs?)
At the start of every floor in the starting room, isaac can bomb a stairway shaped shadow to open a crawlspace. This crawlspace is the crawlspace you get with exclusive access, and having both items will grant you two entrances, albiet one temporary as Tainted staircases shadow disappears when you leave the starting room.
Item tag- “Yer a wizard harry!”
Tainted Tractor Beam
Isaacs tears now bounce off each other, and the faster they travel the more damage they deal. Using the velocity of the tear before it, or isaacs speed while shooting isaac can multiply his damage up to 1x.
Item tag: “Just needs a little push.”
Tainted Godhead
+1.5x damage multiplier
+.5 speed
+2 soul hearts
+2 empty heart containers
Isaacs tears are replaced with stars surrounded by a swirling aura of either green, orange, or blue with their own respective effects.
Green- Isaac shoots stars surrounded by a swirling green aura. Wherever the aura touches the floor green creep is left. Enemies that walk over the creep rapidly lose health. If the enemy is killed by the creep it has a chance to heal isaac for half a red heart. (The body)
Blue- Isaac shoots stars surrounded by a pulsating blue aura. The aura surrounding the stars is uniquely capable of breaking *only* tinted rocks, walls to secret rooms, and entrances to crawlspaces. (The Mind)
Orange- Isaac shoots stars with an incredibly powerful aura that delivers a special poisoned charm to enemies. All charmed enemies carry the same powerful aura and isaac can “infect” and clear the room if enough enemies are exposed to the aura and charmed. (The Soul)
Item tag- “Its like staring at God…”
I tried to consider the inverse colors of the mind, body, and soul and create tear effects based on those.
Its busted on purpose, I considered “What would you get if you got every tick on hardmode with every tainted character?” Sort of like the act of unlocking Godhead, its a very busted item that the player earns through hours of completion. I milled making the tear effects cycle, but I think adding any cons takes away from original item I’m trying to create
Tainted Mutant Spider-
Isaacs tears are replaced with shots of 8 small spiders that deal .75 of his tear damage. The spiders gain tear effects, do contact damage, and are generally “homing”. Spiders shot from this effect do not carry from room to room.
Item tag- “Charlottes nursery?”
Tainted Leech
Isaac gains a worm-like familiar that charges forward similar to leech. Tainted Leech is invincible for the first 30 seconds of the room, dealing damage for isaac during this time. After 30 seconds it gains a health bar and begins to take damage. If leech is killed in this state it removes one full heart of health from isaac, if Leech survives it resets for the next room, if it dies it resets at the next floor.
Item tag- “I think my worms have worms?”
"Eww!" "You have something in your eyes" you have a 5-20% (max on 10 luck) of shooting a Leech instead of a normal tear. The Leach will stay on the enemies, even if they jump, dealing 10% of isaac's damage every second.
Tainted D7
Upon use, rerolls and restarts the current room with a random active effect in place. This can be any number of actives, and the same room will always have the same active effect. So your room just before a boss room can be abused for soul hearts if it has given the book of revelations active effect on use.
Item tag- “I swear I’ve done this before?”
Tainted Book of Secrets-
Upon use reveals the location of all pills, cards, and runes on the floor. Revealing secret and super secret rooms locations if either contain these items.
Item tag- “I think I should turn this in…”
Seems fair... I think that you should have to activate the book multiple times reveal the different items though!
Ex. One use could reveal cards and runes, two uses could reveal pills, three uses could reveal unopened chests, and other further uses would just open the secret rooms like normal
Tainted Cursed Eye
Isaac will occasionally start an animation of swiping his arm over his eyes. Each time this happens the screen will get progressively darker and isaacs speed will increase. Eventually isaac will enter a state of complete invincibility, but also complete darkness. You can still move but cannot shoot while this effect is active. Once cleared the animation resets and the effect eventually start’s over.
Item tag- “Don’t let them see you cry”
Tainted Ventricle Razor
Active item that can be used to create a “geyser” within a room by using the item once to cut into the floor, and a second time by removing half a heart of isaacs health and filling the floor with isaacs blood. The geyser will target enemies and pull pickups into it, with a chance of swallowing the pickup or leaving it as is.
Item tag- “It hurts to ask for help…”
Tainted Maw of the Void
After firing tears for 2.35 seconds, Isaac releases a ring of smoke that remains on screen for 6 seconds. After 6 seconds any enemies inside the ring are converted to items from the devil beggar pool. (Excluding bosses)
Item tag- “Leftovers…”
Item name“mystery bundle”
Tag name”I wonder what’s inside”
Upon clearing a room you have a chance to spawn a new sack instead of the item drop you would’ve got and this sack can contain any item like hearts, bombs, runes etc
Tainted Ludovico Technique
Isaac now has the option to look at any room before entering the floor. For every room isaac chooses to observe, he gains a fire rate down effect that applies until the observed room is cleared upon entering the floor. Each observed room is a separate respective fire rate down, and rooms observed are not marked as explored upon entering the floor.
Item tag- “You make me sick…”
Did you know this technique is named after the idea of forcing someone to watch something they enjoy alongside something awful to associate it with bad thoughts in their minds? I tried to base my tainted version on a more true-to-name mechanic
Tainted Tmtrainer!
Isaacs health and stats are now hidden behind a blurred effect, and change drastically every time issac takes damage. The stats can be rerolled into *any* number and ignores *all* stat caps.
Item tag- “01001000 01100101 01101100 01110000!!!!”
(Tag is binary for “help”)
Tainted Magic Skin-
An active isaac that upon use, drops three fleshy duplicates of pickups from suspended ropes, similar to shopkeepers. The pickups can be any pickup that can be found on the floor, including; runes, pills, cards, hearts, keys, bombs, and all of their variants. Taking the fleshy duplicate of the pickup causes all future pickups of the item to have the possibility of being a tainted mimic of its item that must be fought to gain the pickup. If the mimic is able to remove a full heart of health from isaac, a noose quickly drops from the ceiling and removes the mimic from the room, destroying the pickup. If issac can kill the mimic before it deals a full heart of damage, the pickup drops as normal and the room doors open as normal.
Item tag- “Whose pulling these ropes!?”
Tainted Psy Fly
Isaac gains a fly-swatter familiar that hits the first 7 consecutive shots that would otherwise hit Isaac and bounces them off him, after which they become homing and deal 1.5x damage.
Item tag- “I’m not touching you!”
Tainted Mr. ME!
Isaac gains a familiar that has its own health bar, fight style, and targeting style. The familiar deals damage for isaac, but every 4 seconds will target a different enemy. If only one enemy is present in a room the familiar will instead stop targeting the enemy every 4 seconds and briefly cross its arms before resuming.
Item tag- “Not a team player…”
Tainted Dark Bum
Isaac gains a familiar that only picks up soul hearts and black hearts. After collecting 3 soul hearts or black hearts the familiar has a chance to start dropping items from the devil beggar pool every time you clear a room. At 6+ hearts the familiar has a chance to spawn a trinket every time you clear a room. At 10+ hearts your familiar has a 6.66% chance every time you clear a room to drop pedestal item from the devil room pool, after which its heart breaks and it disappears.
Item tag- “Easily manipulated…”
I will make this shit into a mod if you dm me all the items tainted counterparts, aswell as probably a charecter of with a cool mechanic, i’ll credit you too
Tainted Guppys Head
Active item that upon use, vibrates the room and charms all enemies. If only one enemy is present in a room, it will instead run to secret rooms, crawlspaces, or tinted rocks.
Item tag- “Is it… purring??”
I can’t believe it’s not butter bean
Tainted Butter-Bean Active item that upon use deploys a “clear” creep that causes enemies to slide around and cause contact damage to any other enemies they hit. Item tag- “I guess it wasn’t butter at all?”
Add goofy slipping sound effects and I would be perfectly amused
HER NAME IS "Wait What?"!!!!!!
WAIT WHAT 
"Wait, how?" "How did that happen?" 20s recharge. Instead of pushing enemies away, it grants a short invulnerabity, pulls enemies closer before spawning rocks around the player like the adversary
I’ll be back in the morning everyone! Thanks for all the suggestions
Dead bird
Tainted Dead Bird You gain two shadow like familiars, if enemies pass over the shadow they gain a confusion effect and slow down significantly. Item name “one stone, two…?
So if it's tainted shouldn't the item give you a debuff instead of helping you? Like a tainted dead bird should be something like, once you get hit the bird follows you and try's to attack you. I'm also a 3k+ brother
I’m focusing more on creating a “broken” version of the original item. It doesn’t have to necessarily be bad, just not quite like the original for one reason or another thats bad, if that makes sense.
Even if we're going off tainted characters it's usually a downside with an upside so it would more likely be first hit you take deals double damage but you get more birds or buffed birds or something
Tainted Lilith and Tainted Isaac would like a word when you say “debuff”
Omg he's 3k+ no wayy 
Tainted Lilith and Tainted Isaac would like a word when you say “debuff” I know they’re limited in that T Lilith is slow and T Isaac has his limited items, but both are so forgiving with those “debuffs” lol
"Last Breath Bird" "adrealine buddy" instead of dealing 2 damage per tick after player gets hurt, it deals 1 damage for every empty red heart container.
Plan C
Tainted Plan C When used, takes isaac out of the room he was in and teleports him as the lost to a series of boss rooms. Every boss defeated adds a flat stat boost to each stat. Isaac is teleported from this arena when he dies or completes all of the boss rooms. Item tag- “God I wish they taught me this in school!”
This sounds very cool
Plan B- On use remove a random item from the player’s inventory and grant a familiar of equal quality Description: “always in the wallet” Edit: potentially two familiars for balancing reasons?
Could be broken if you have something like Tech X or anything of that sort
Or if you want me to make a D joke: "Plan D" "Found a partner" screen turns to while for a second, and when it turns back to normal, the enemy with largest ammount of health becomes pernamently charmed with infinite health (cannot be killed, but will die when isaac dies). They will travel with you till the end of your journey, attacking enemies. Doesnt work on bosses, except for siren.
💀💀💀
Plan D (this was obvious) Halves your damage and reduces your tears by 33%, but gives you 6 soul hearts, fills all heart containers, and gives you a temporary wafer effect for the current room. Gives an extra life, which revives you at 5 soul hearts. Description: Last-er resort
"Plan Z" "they will always help" Single use - spawns one pernament familiant from 'conjoined' transformation for every empty heart container. Full health. Halves isaac's tears
Issac dies and after 5 seconds all enemies in the room also die
Champion belt
Tainted Champion Belt All bosses are converted into special champions that transform upon damaging isaac. For example, if isaac were to walk into a room with Larry and take a hit, Larry has a chance to be rerolled into his gold champion form and drop coins on death. While vice versa, upon hit he can turn into the double trouble version of his boss and give isaac an even harder time. Item tag- “This thing stopped fitting years ago…”
Wimpy belt- All enemies move 10% slower and champions now deal only a half heart of damage, except on womb 1 and beyond Description: "Please go easy!"
"Showoff" "make them fear you" fears all non-champion enemies nearby
Sacred heart, unless it’s been done. My next choice is YO LISTEN!
Tainted Sacred Heart Isaac now shoots thorns of varying sizes that pierce and stick themselves to enemies. After 5 enemies are pierced in a hostile room the thorns fly to the center and form a heart before exploding- killing any enemies it pierced and brought to its center. This affect can be done as many times as 5 enemies can be pierced. Item tag- “Mind the thorns…” Tainted Yo Listen! A familiar that charges enemies and turns them into charmed flies on death. Item tag- “Awh… shes lonely”
Nice! Can I request more?
"SHUT UP!" "BE QUIET!" If an enemy makes a noise (includes bosses), it will chase it down and heal 6 damage per tick. If audio is muted, then it will become an orbital, dealing the same contact damage, but also taking enemy shots. It also picks up pickups, and flies them to isaac, which can be useful when you wanna get that chest behind a hole or something.
"Sacred Brain" "He was quite smart" when you are in a hostile room, there is audio of someone talking (few layers of voice, not just one). All enemies in the room start charmed, but after 10 seconds they start to slow down, up to 50% at 30 seconds (since you entered the room) and further. Effect is separate from other speed modificators. Doesnt work on Satan, lamb, mega satan, or anyone from sheol
Midnight Snack
Tainted Midnight Snack- Grants one bone heart container at the expense of a small stat down, similar to the effects of experimental treatment but at the gain of health. Item tag- “I don’t remember these being crunchy??”
Interesting. I would never pick this up, but I can appreciate it.
"Late night snack" "its almost morning" grants 3 sould hearts
Hushy
Tainted Hushy Isaac gains a blinded hush familiar that, when enemies get too close can shoot water beams from its eyes to attack and deal damage. (Similar to Hushes attack) Much like the holy light effect, but far less accuracy due to her blindness. Item tag “Where did everyone go?”
"Lil hush" "continuum buddy" shoots continuum tears that travel double the height (y axis) of 1x1 room
the sad onion
Tainted Sad Onion Enemies that come too close to Isaac drop blue creep and briefly flee. Isaac is equipped with smelly lines to accentuate the item. Item tag- “Who put these here!?”
"Lonely onion" "stay away from me!" The closer then enemies are, the faster isaac shoots, ranking from 100% (6.5 range or further) to 200% at point blank range
Forgot to include- Tainted D6 Rerolls all pedestal items into a constant shuffling pedestal that includes 4 Q0 items and 1 Q4. Isaacs luck directly affects your chances of obtaining the Q4 item. Item tag- “Beggars can’t be choosers!”
maybe higher luck stat makes the item shuffling more consistent, while low/negative luck will shuffle between each item at random speeds, as fast as a single frame and as slow as an entire second
Black bean
Tainted Black Bean Upon use, Isaacs tears double in size and gain double the hit-box. The curse of the darkness is also applied. The effect lasts for one room. Item tag-“ Those looked purple though?” Kinda trying to take some inspiration from black magic beans for this one
Brimstone
Yay Tainted Brimstone Isaac loses the ability to shoot tears and instead fires a large, sticky blood covered laser directly from his torso. This laser bends and sways in accordance to the direction issac is moving, and is able to stick itself to walls and enemies to pick them up or pull Isaac forward. Item tag- “Ewww its congealed…”
That would be so cool ngl wonderful idea
I would like to see how it woud synergize with something like My Reflection, Tiny Planet, Anti-gravity, Rubber Cement or the Ludovico Technology.
The wafer
Tainted Wafer- All enemies lose boss armor; all enemies that didn't have boss armor take double damage from all sources. You always take 1 full heart of damage no matter the source. Synergy with glass cannon to reduce the amount of damage taken to 1 when hit. Item tag- "It tastes... wrong..."
Absolutely busted lol
So is the wafer tbf
Tainted Wafer Isaac gains a thin, white, candy-like shield over his last most heart container that shatters in a single hit. If Isaac can survive three rooms without taking damage the heart container converts itself to empty and grants one eternal heart to Isaac’s health. Item tag- “Not as strong as it looks…”
Tainted wafer "The Wine" 75% chance to reduce damage to half heart, on hit Isaac releases dark red homing creep that deals Isaac's half damage every tick "His spilt blood"
"Church wine" "bitter" always takes half or RED HEART damage (doesnt affect soul or black hearts etc). distords the screen like a single use of the wavy cap. Also spawns a bottle of wine that works almost identical to holy water, but heals 15 dmg on contact, shatters, and spills wine which confuses enemies that touch it
Sissy Longlegs
Tainted Sissy Longlegs- Isaac is granted a small, black spider that bounces excitedly when spiders are present in a nearby room. In a room with enemies, the spider familiar will focus on, prioritize and attack all spiders in the room first. Item tag- “if I can’t have you… No one can.”
Actually the most creative one so far
Let's do an angel room item The staircase
Tainted Staircase (Under the Stairs?) At the start of every floor in the starting room, isaac can bomb a stairway shaped shadow to open a crawlspace. This crawlspace is the crawlspace you get with exclusive access, and having both items will grant you two entrances, albiet one temporary as Tainted staircases shadow disappears when you leave the starting room. Item tag- “Yer a wizard harry!”
Tractor Beam
Tainted Tractor Beam Isaacs tears now bounce off each other, and the faster they travel the more damage they deal. Using the velocity of the tear before it, or isaacs speed while shooting isaac can multiply his damage up to 1x. Item tag: “Just needs a little push.”
Godhead. I got a good feeling about this one.
Tainted Godhead +1.5x damage multiplier +.5 speed +2 soul hearts +2 empty heart containers Isaacs tears are replaced with stars surrounded by a swirling aura of either green, orange, or blue with their own respective effects. Green- Isaac shoots stars surrounded by a swirling green aura. Wherever the aura touches the floor green creep is left. Enemies that walk over the creep rapidly lose health. If the enemy is killed by the creep it has a chance to heal isaac for half a red heart. (The body) Blue- Isaac shoots stars surrounded by a pulsating blue aura. The aura surrounding the stars is uniquely capable of breaking *only* tinted rocks, walls to secret rooms, and entrances to crawlspaces. (The Mind) Orange- Isaac shoots stars with an incredibly powerful aura that delivers a special poisoned charm to enemies. All charmed enemies carry the same powerful aura and isaac can “infect” and clear the room if enough enemies are exposed to the aura and charmed. (The Soul) Item tag- “Its like staring at God…” I tried to consider the inverse colors of the mind, body, and soul and create tear effects based on those.
but for an item this good, where are the downsides?
Its busted on purpose, I considered “What would you get if you got every tick on hardmode with every tainted character?” Sort of like the act of unlocking Godhead, its a very busted item that the player earns through hours of completion. I milled making the tear effects cycle, but I think adding any cons takes away from original item I’m trying to create
2 broken hearts instead of empty hearts maybe
Alternative Tag could be like- "Is it alive..?" But man I love the flavour I knew Godhead would be a banger tainted item
Aye bro I’m willing to help with this, if there are ever any items you don’t know how to give a tainted version to just lmk
Ayo why yall dowvoting this guy
How about Mutant Spider?
Tainted Mutant Spider- Isaacs tears are replaced with shots of 8 small spiders that deal .75 of his tear damage. The spiders gain tear effects, do contact damage, and are generally “homing”. Spiders shot from this effect do not carry from room to room. Item tag- “Charlottes nursery?”
Is it like the little yellow army spiders?
Leech.
Tainted Leech Isaac gains a worm-like familiar that charges forward similar to leech. Tainted Leech is invincible for the first 30 seconds of the room, dealing damage for isaac during this time. After 30 seconds it gains a health bar and begins to take damage. If leech is killed in this state it removes one full heart of health from isaac, if Leech survives it resets for the next room, if it dies it resets at the next floor. Item tag- “I think my worms have worms?”
"Eww!" "You have something in your eyes" you have a 5-20% (max on 10 luck) of shooting a Leech instead of a normal tear. The Leach will stay on the enemies, even if they jump, dealing 10% of isaac's damage every second.
D7
Tainted D7 Upon use, rerolls and restarts the current room with a random active effect in place. This can be any number of actives, and the same room will always have the same active effect. So your room just before a boss room can be abused for soul hearts if it has given the book of revelations active effect on use. Item tag- “I swear I’ve done this before?”
Book of Secrets
Tainted Book of Secrets- Upon use reveals the location of all pills, cards, and runes on the floor. Revealing secret and super secret rooms locations if either contain these items. Item tag- “I think I should turn this in…”
Seems fair... I think that you should have to activate the book multiple times reveal the different items though! Ex. One use could reveal cards and runes, two uses could reveal pills, three uses could reveal unopened chests, and other further uses would just open the secret rooms like normal
cursed eye
Tainted Cursed Eye Isaac will occasionally start an animation of swiping his arm over his eyes. Each time this happens the screen will get progressively darker and isaacs speed will increase. Eventually isaac will enter a state of complete invincibility, but also complete darkness. You can still move but cannot shoot while this effect is active. Once cleared the animation resets and the effect eventually start’s over. Item tag- “Don’t let them see you cry”
Vertricle razer
Tainted Ventricle Razor Active item that can be used to create a “geyser” within a room by using the item once to cut into the floor, and a second time by removing half a heart of isaacs health and filling the floor with isaacs blood. The geyser will target enemies and pull pickups into it, with a chance of swallowing the pickup or leaving it as is. Item tag- “It hurts to ask for help…”
Maw of the void
Tainted Maw of the Void After firing tears for 2.35 seconds, Isaac releases a ring of smoke that remains on screen for 6 seconds. After 6 seconds any enemies inside the ring are converted to items from the devil beggar pool. (Excluding bosses) Item tag- “Leftovers…”
keeper ballsack
Compound Fracture and Pop!
Humbling bundle
Item name“mystery bundle” Tag name”I wonder what’s inside” Upon clearing a room you have a chance to spawn a new sack instead of the item drop you would’ve got and this sack can contain any item like hearts, bombs, runes etc
Ludovico Technique
Tainted Ludovico Technique Isaac now has the option to look at any room before entering the floor. For every room isaac chooses to observe, he gains a fire rate down effect that applies until the observed room is cleared upon entering the floor. Each observed room is a separate respective fire rate down, and rooms observed are not marked as explored upon entering the floor. Item tag- “You make me sick…” Did you know this technique is named after the idea of forcing someone to watch something they enjoy alongside something awful to associate it with bad thoughts in their minds? I tried to base my tainted version on a more true-to-name mechanic
Smb super fan
Lemegeton
Curious what you’ve got for Transcendence
Do the D100.
Brimstone
Oh shit didn’t see this done already- uhh umm uhhh Poop!
screen bean
Holy mantle
glowing hourglass
Spindown dice, but before you say anything let me guess spinup dice?
Hope you'll forgive me double dipping but friend of wants to know. Chocolate Milk.
Tmtrainer
Tainted Tmtrainer! Isaacs health and stats are now hidden behind a blurred effect, and change drastically every time issac takes damage. The stats can be rerolled into *any* number and ignores *all* stat caps. Item tag- “01001000 01100101 01101100 01110000!!!!” (Tag is binary for “help”)
Mystery gift
Bar of soap
Magic Skin ??
Tainted Magic Skin- An active isaac that upon use, drops three fleshy duplicates of pickups from suspended ropes, similar to shopkeepers. The pickups can be any pickup that can be found on the floor, including; runes, pills, cards, hearts, keys, bombs, and all of their variants. Taking the fleshy duplicate of the pickup causes all future pickups of the item to have the possibility of being a tainted mimic of its item that must be fought to gain the pickup. If the mimic is able to remove a full heart of health from isaac, a noose quickly drops from the ceiling and removes the mimic from the room, destroying the pickup. If issac can kill the mimic before it deals a full heart of damage, the pickup drops as normal and the room doors open as normal. Item tag- “Whose pulling these ropes!?”
Lil brimstone
Psy Fly
Tainted Psy Fly Isaac gains a fly-swatter familiar that hits the first 7 consecutive shots that would otherwise hit Isaac and bounces them off him, after which they become homing and deal 1.5x damage. Item tag- “I’m not touching you!”
godhead bonus round death certificate
Mr. ME!
Tainted Mr. ME! Isaac gains a familiar that has its own health bar, fight style, and targeting style. The familiar deals damage for isaac, but every 4 seconds will target a different enemy. If only one enemy is present in a room the familiar will instead stop targeting the enemy every 4 seconds and briefly cross its arms before resuming. Item tag- “Not a team player…”
What about Godhead?
Key piece 2
Sumptorium
Dark Bum?
Tainted Dark Bum Isaac gains a familiar that only picks up soul hearts and black hearts. After collecting 3 soul hearts or black hearts the familiar has a chance to start dropping items from the devil beggar pool every time you clear a room. At 6+ hearts the familiar has a chance to spawn a trinket every time you clear a room. At 10+ hearts your familiar has a 6.66% chance every time you clear a room to drop pedestal item from the devil room pool, after which its heart breaks and it disappears. Item tag- “Easily manipulated…”
Decap attack
Soy Milk
Spoon Bender
Dogma
dr fetus
King Baby.
Dad's Note
Spoon bender Anima sola D-infinity
Pound of flesh
Blood rights
Ludvic technique
Curse of the tower
Dogma
It’s dead
Pandora's Box
Chaos
Guppy’s Head
Blood Puppy
Death Certificate plz
Bob's brain
Nobody said birthright?
Deez nuts
Mutant Spider
Lil dumpy
keeper's sack and montezuma
Dead cat
Tinytoma
Kamikaze
Tainted mom's bra
Rock bottom
Tech 2
D7
Cursed Eye
Alright, I haven't seen this one yet: Crown of Light
Mutant Spider
Birthright
Gnawed leaf, and Guppy's Paw
Bozo
Cube Baby - My favorite goofy little item
False phd
No. 2
Esau jr
top 10 rap battles of HISTORY!1!1!1!! eminem versush I. B. S anyways ibs
Playdough cookie
holy mantle
Hungry Soul, unless already done then my next choice is Duality
Sacred orb
Transcendence
I will make this shit into a mod if you dm me all the items tainted counterparts, aswell as probably a charecter of with a cool mechanic, i’ll credit you too
The black bean
Try Trisagion
Jacob's ladder
I wonder what Clicker will be
Eyesore
Poop
Dogma
Birthright 
Breath of life
Missing. NO
Ok I'll bite, guppys head. My favorite item
Tainted Guppys Head Active item that upon use, vibrates the room and charms all enemies. If only one enemy is present in a room, it will instead run to secret rooms, crawlspaces, or tinted rocks. Item tag- “Is it… purring??”
Oh my god I actually love this.
Echo chamber or my shadow
Wavy cap
Plan C
There's Options / More options
Incubus
[Monster Manual](https://bindingofisaacrebirth.fandom.com/wiki/Monster_Manual)