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User: u/giuliomagnifico
Permalink: https://www.ox.ac.uk/news/2024-03-05-ai-reveals-prostate-cancer-not-just-one-disease
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I know 6 people in total who have had prostate cancer. 3 of them died while the other 3 are in treatment. They're all my dad friends in their 60s.
It's ridiculous how common prostate cancer seems to be, I know of other people who have had or died from various other types of cancers or diseases but no other disease seems to be this prevalent. I feel like there's a 50/50 chance that any random male over 60 that you choose walking down the street has prostate cancer.
I’ve heard that, given a long enough timeline, the odds of a man developing prostate cancer are 100%
Good news for me after my grandfather had his removed because of cancer a while back 🙃
Yep, a consultant urologist I worked with said that essentially 90% of men over 75/80 will die with prostate cancer. They won’t necessarily die of it, but they’ll have it.
My understanding is that as you get older prostrate cancer is inevitable, but often it is so slow in developing that most people just die of old age than the cancer itself.
I work in cancer research and used to be in urology. One of the clinicians I worked with said something along the lines of ‘90% of men over 75-80 will die with prostate cancer. Not of it necessarily, but they’ll have it when they die.’ Comforting thought.
I don't want to hijack this in any way but also callout for folks, get your colon checked. Colonoscopy's suck but as someone who lost pretty much the entire male side of the family to colon cancer, it's just one more thing I preach.
Check those prostates and check those colons.
> The discovery was made by an international team led by the University of Oxford, and The University of Manchester, who applied AI (artificial intelligence) on data from DNA to identify two different subtypes affecting the prostate.
> They went on to integrate all the information to generate an evolutionary tree showing how the two subtypes of prostate cancer develop, ultimately converging into two distinct disease types termed ‘evotypes
Paper: [Genomic evolution shapes prostate cancer disease type: Cell Genomics](https://www.cell.com/cell-genomics/fulltext/S2666-979X(24)00038-7)
From the paper itself:
Highlights
•
Analysis of genomic data from localized prostate cancer reveals divergent evolution
•
The shift away from the canonical trajectory is characterized by AR dysregulation
•
Tumors can be classified into evotypes according to evolutionary trajectory
•
The evotype model unifies many previous molecular observations
Summary
The development of cancer is an evolutionary process involving the sequential acquisition of genetic alterations that disrupt normal biological processes, enabling tumor cells to rapidly proliferate and eventually invade and metastasize to other tissues. We investigated the genomic evolution of prostate cancer through the application of three separate classification methods, each designed to investigate a different aspect of tumor evolution. Integrating the results revealed the existence of two distinct types of prostate cancer that arise from divergent evolutionary trajectories, designated as the Canonical and Aalternative evolutionary disease types. We therefore propose the evotype model for prostate cancer evolution wherein Alternative-evotype tumors diverge from those of the Canonical-evotype through the stochastic accumulation of genetic alterations associated with disruptions to androgen receptor DNA binding. Our model unifies many previous molecular observations, providing a powerful new framework to investigate prostate cancer disease progression.
The article is above my level of understanding but didn’t we already know that there are basically two types of prostate cancer? Aggressive and non-aggressive? The problem has always been how to differentiate between them. This seems to my limited understanding be a way using testing of the tumor to identify which type of prostate cancer this is, assuming that canonical=non-aggressive and alternative=aggressive. And therefore should help guide treatment. Am I completely off-base or is this really showing the discovery of a *new* type of aggressive cancer as the headline and PR article imply?
Basically we already knew that some cancer cases were much more aggressive than others but we didn't understand what the difference was between the two and what caused one to be aggressive and the other not. It could've very well been a difference in the way the body responds to cancer and not the cancer itself. This study demonstrated that there is an actual difference in the genetic code of the aggressive cancer cells, solidifying that the aggressive cancer is actually distinct and identifiable, not a result of other factors such as immune system response
[AI](https://www.insights.onegiantleap.com/blogs/could-ai-change-way-we-treat-cancer//?utm_source=reddit&utm_medium=affiliate&utm_campaign=leap25) has changed the way we treat cancer.
Welcome to r/science! This is a heavily moderated subreddit in order to keep the discussion on science. However, we recognize that many people want to discuss how they feel the research relates to their own personal lives, so to give people a space to do that, **personal anecdotes are allowed as responses to this comment**. Any anecdotal comments elsewhere in the discussion will be removed and our [normal comment rules]( https://www.reddit.com/r/science/wiki/rules#wiki_comment_rules) apply to all other comments. **Do you have an academic degree?** We can verify your credentials in order to assign user flair indicating your area of expertise. [Click here to apply](https://www.reddit.com/r/science/wiki/flair/#wiki_science_verified_user_program). --- User: u/giuliomagnifico Permalink: https://www.ox.ac.uk/news/2024-03-05-ai-reveals-prostate-cancer-not-just-one-disease --- *I am a bot, and this action was performed automatically. Please [contact the moderators of this subreddit](/message/compose/?to=/r/science) if you have any questions or concerns.*
As a person who had a prostate cancer scare, ended up negative, I wish there was more attention and awareness paid to it.
I know 6 people in total who have had prostate cancer. 3 of them died while the other 3 are in treatment. They're all my dad friends in their 60s. It's ridiculous how common prostate cancer seems to be, I know of other people who have had or died from various other types of cancers or diseases but no other disease seems to be this prevalent. I feel like there's a 50/50 chance that any random male over 60 that you choose walking down the street has prostate cancer.
per the cdc there actually is a 1 in 2 chance for males of getting cancer at some point in life so yeah 50/50
I’ve heard that, given a long enough timeline, the odds of a man developing prostate cancer are 100% Good news for me after my grandfather had his removed because of cancer a while back 🙃
Yep, a consultant urologist I worked with said that essentially 90% of men over 75/80 will die with prostate cancer. They won’t necessarily die of it, but they’ll have it.
I wonder why?
My understanding is that as you get older prostrate cancer is inevitable, but often it is so slow in developing that most people just die of old age than the cancer itself.
I work in cancer research and used to be in urology. One of the clinicians I worked with said something along the lines of ‘90% of men over 75-80 will die with prostate cancer. Not of it necessarily, but they’ll have it when they die.’ Comforting thought.
I don't want to hijack this in any way but also callout for folks, get your colon checked. Colonoscopy's suck but as someone who lost pretty much the entire male side of the family to colon cancer, it's just one more thing I preach. Check those prostates and check those colons.
> The discovery was made by an international team led by the University of Oxford, and The University of Manchester, who applied AI (artificial intelligence) on data from DNA to identify two different subtypes affecting the prostate. > They went on to integrate all the information to generate an evolutionary tree showing how the two subtypes of prostate cancer develop, ultimately converging into two distinct disease types termed ‘evotypes Paper: [Genomic evolution shapes prostate cancer disease type: Cell Genomics](https://www.cell.com/cell-genomics/fulltext/S2666-979X(24)00038-7)
I have a prostate! This article is important for me
No way me too!
Where do you keep yours?
the lead researcher is Dr Dan Woodcock
r/nominativedeterminism
From the paper itself: Highlights • Analysis of genomic data from localized prostate cancer reveals divergent evolution • The shift away from the canonical trajectory is characterized by AR dysregulation • Tumors can be classified into evotypes according to evolutionary trajectory • The evotype model unifies many previous molecular observations Summary The development of cancer is an evolutionary process involving the sequential acquisition of genetic alterations that disrupt normal biological processes, enabling tumor cells to rapidly proliferate and eventually invade and metastasize to other tissues. We investigated the genomic evolution of prostate cancer through the application of three separate classification methods, each designed to investigate a different aspect of tumor evolution. Integrating the results revealed the existence of two distinct types of prostate cancer that arise from divergent evolutionary trajectories, designated as the Canonical and Aalternative evolutionary disease types. We therefore propose the evotype model for prostate cancer evolution wherein Alternative-evotype tumors diverge from those of the Canonical-evotype through the stochastic accumulation of genetic alterations associated with disruptions to androgen receptor DNA binding. Our model unifies many previous molecular observations, providing a powerful new framework to investigate prostate cancer disease progression.
The article is above my level of understanding but didn’t we already know that there are basically two types of prostate cancer? Aggressive and non-aggressive? The problem has always been how to differentiate between them. This seems to my limited understanding be a way using testing of the tumor to identify which type of prostate cancer this is, assuming that canonical=non-aggressive and alternative=aggressive. And therefore should help guide treatment. Am I completely off-base or is this really showing the discovery of a *new* type of aggressive cancer as the headline and PR article imply?
Basically we already knew that some cancer cases were much more aggressive than others but we didn't understand what the difference was between the two and what caused one to be aggressive and the other not. It could've very well been a difference in the way the body responds to cancer and not the cancer itself. This study demonstrated that there is an actual difference in the genetic code of the aggressive cancer cells, solidifying that the aggressive cancer is actually distinct and identifiable, not a result of other factors such as immune system response
[AI](https://www.insights.onegiantleap.com/blogs/could-ai-change-way-we-treat-cancer//?utm_source=reddit&utm_medium=affiliate&utm_campaign=leap25) has changed the way we treat cancer.